| Media | Actor | Character | Notes |
|---|---|---|---|
| Dominion | Anthony Head | David Whele | - |
| National Treasure: Book of Secrets | Christian Camargo | John Wilkes Booth | - |
| Black Dynamite | James McManus | Richard Nixon | same gun used to shoot Lincoln |
| North and South: Book II | Jean Simmons | Clarissa Main | Nickel plated |
| Fear the Walking Dead - Season 5 | Jenna Elfman | June | "Humbug's Gulch" (S5E03) |
| Killing Lincoln | Jesse Johnson | John Wilkes Booth | - |
| Bedazzled | Julian Firth | John Wilkes Booth | - |
| The Conspirator | Toby Kebbell | John Wilkes Booth | - |