| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Alec Craig | Radlik | Colt Detective Special | - |
| Basil Rathbone | Sherlock Holmes | Colt Detective Special | - |
| Basil Rathbone | Sherlock Holmes | Colt Model 1908 Vest Pocket | - |
| Basil Rathbone | Sherlock Holmes | Remington Model 34 | - |
| Basil Rathbone | Sherlock Holmes | Colt Police Positive | Only on a promotional image |
| Harry Cording | Fred Garvin | Colt Detective Special | - |
| Nigel Bruce | Dr. Watson | Colt Detective Special | - |
| Nigel Bruce | Dr. Watson | Remington Model 34 | - |
| Vernon Downing | Norman Locke | Colt 1877 Thunderer Shopkeeper Model | - |
| Vernon Downing | Norman Locke | Pump action small caliber rifle | - |