| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Laurence Fishburne | Morpheus | Desert Eagle | - |
| Laurence Fishburne | Morpheus | Glock 18 | - |
| Laurence Fishburne | Morpheus | Walther P99 | - |
| Carrie-Anne Moss | Trinity | Beretta 92FS Compact | - |
| Carrie-Anne Moss | Trinity | Micro Uzi | - |
| Talk:Adrian and Neil Rayment | Twin | Heckler & Koch UMP-45 | Modified forend, C-more sight |
| Anthony Brandon Wong | Ghost | SIG-Sauer P229 | - |
| Daniel Bernhardt | Agent Johnson | Desert Eagle | - |
| Hugo Weaving | Agent Smith | Desert Eagle Mark XIX | - |
| Matt McColm | Agent Thompson | Desert Eagle | polished blued finish |
| Monica Bellucci | Persephone | COP 357 Derringer | pearl grips, silver bullets |