| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Amanda Abbington | Mary Morstan | Walther PPK | "His Last Vow" (S03E03); suppressed |
| Amanda Abbington | Mary Watson | Beretta 92FS Inox | "The Six Thatchers" (S04E01) |
| Sacha Dhawan | Ajay | Beretta 92FS | "The Six Thatchers" |
| Sacha Dhawan | Ajay | Glock 17 | Stainless slide; "The Six Thatchers" |