| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Samuel L. Jackson | Nick Fury | Smith & Wesson M&P | holstered |
| Scarlett Johansson | Natasha Romanoff | Glock 26 | dual wielded |
| Scarlett Johansson | Natasha Romanoff | Glock 19 | - |
| Scarlett Johansson | Natasha Romanoff | Makarov PM | - |
| Aaron Taylor-Johnson | Pietro Maximoff / Quicksilver | RPK | - |
| Andy Serkis | Ulysses Klaue | Beretta 90Two | - |
| Cobie Smulders | Maria Hill | Walther PPK | two-tone |
| Cobie Smulders | Maria Hill | Glock 17 | - |