| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Andrew Scott | James "Jim“ Moriarty | Beretta 92FS Inox | "The Reichenbach Fall" (S2E3) |
| Benedict Cumberbatch | Sherlock Holmes | Glock 17 | "A Scandal in Belgravia" (S2E01), "The Reichenbach Fall" (S2E03) |
| Martin Freeman | Dr. John Watson | Beretta 92FS Inox | "The Hounds of Baskerville" (S02E02); Airsoft replica |
| Russell Tovey | Henry Knight | Beretta 92FS Inox | "The Hound of Baskerville" (S02E02) |
| Todd Boyce | CIA Agent Neilson | Glock 17 | "A Scandal in Belgravia" (S02E01) |