| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Andrew Scott | Professor James Moriarty | Smith & Wesson Safety Hammerless | - |
| Benedict Cumberbatch | Sherlock Holmes | Webley RIC No.1 New Model | - |
| Martin Freeman | Dr. John Watson | Webley Mark II | - |
| Natasha O'Keeffe | Emelia Ricoletti aka "The Abominable Bride" | Colt 1878 Double Action | - |
| Natasha O'Keeffe | Emelia Ricoletti aka "The Abominable Bride" | Double Barreled Shotgun | - |