| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Ann Robinson | Officer Grace Downey | Colt Detective Special | - |
| Dan Aykroyd | Sgt. Joe Friday | Smith & Wesson Model 10 | - |
| Dan Aykroyd | Sgt. Joe Friday | Mossberg 500 | - |
| Dan Aykroyd | Sgt. Joe Friday | Taurus PT92 | - |
| Jack O'Halloran | Emil Muzz | Micro Uzi | - |
| Jack Webb | Det. Sgt. Joe Friday | Colt Detective Special | - |
| Tom Hanks | Det. Pep Streebeck | Colt Python | Chrome finish, 6" barrel |