| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Anna Belknap | Det. Lindsay Monroe Messer | Glock 26 | - |
| Anna Belknap | Det. Lindsay Monroe Messer | Glock 17 | - |
| Carmine Giovinazzo | Det. Danny Messer | Glock 17 | - |
| Carmine Giovinazzo | Det. Danny Messer | AKM | - |
| Carmine Giovinazzo | Det. Danny Messer | Smith & Wesson Model 36 | - |
| David Caruso | Lt. Horatio Caine | SIG-Sauer P229 | "Manhattan Manhunt" |
| Eddie Cahill | Det. Donald Flack Jr. | Glock 17 | - |
| Eddie Cahill | Det. Donald Flack Jr. | Glock 19 | - |
| Eddie Cahill | Det. Donald Flack Jr. | SIG-Sauer P226 Elite Stainless | Starting inSeason 7 |
| Eion Bailey | Dean Lessing | M16A2 rifle | "Charge of This Post" |
| Gary Sinise | Det. Mac Taylor | Glock 17 | - |
| Gary Sinise | Det. Mac Taylor | Beretta 92FS | "Snow Day" |
| Hill Harper | Dr. Sheldon Hawkes | Glock 17 | - |
| Melina Kanakaredes | Det. Stella Bonasera | Glock 17 | - |
| Melina Kanakaredes | Det. Stella Bonasera | Glock 26 | - |
| Melina Kanakaredes | Det. Stella Bonasera | Beretta 3032 Tomcat | - |
| Melina Kanakaredes | Det. Stella Bonasera | M4A1 Carbine | ACOG scope, RIS foregrip, and tactical flashlight |
| Melina Kanakaredes | Det. Stella Bonasera | Kriss Super V | - |
| Ne-Yo | The Handsome Man | Glock 17 | "Smooth Criminal" |
| Ne-Yo | The Handsome Man | Mossberg 500 Cruiser | "Smooth Criminal" |
| Sela Ward | CSI Jo Danville | Glock 26 | - |