| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Annabella Sciorra | Det. Carolyn Barek | Glock 26 | - |
| Bokeem Woodbine | Joshua Alexander | Jericho 941 | "Flipped", (S6E14) |
| Chris Noth | NYPD Det. Mike Logan | Colt Detective Special | 3rd Generation |
| Chris Noth | NYPD Det. Mike Logan | Glock 17 | 3rd Generation |
| Clifton Powell | Dempsey Powers | SIG-Sauer P232 | "Cuba Libre" (S2E16) |
| David Keith | Detective Mark Virgini | Glock 19 | "Unchained" (S5E04) |
| David Warshofsky | Officer Ray Wiznesky | Smith & Wesson Model 36 | Nickel; "Siren Call" (S6E03) |
| Jake Weber | Karl Atwood | Budischowsky/Norton TP-70 | "One" (S1E01) |
| Jake Weber | Karl Atwood | Pocket Pistol Non Gun | "One" (S1E01) |
| Jamey Sheridan | Capt. Deakins | Ithaca 37 | "Pilgrim" (S2E08) |
| Jeff Goldblum | Det. Zach Nichols | Kahr M9098 Elite 2003 | - |
| Julianne Nicholson | Detective Megan Wheeler | Glock 26 | - |
| Kathryn Erbe | Det. Alexandra Eames | Glock 19 | "One" (S1E01) |
| Kathryn Erbe | Det. Alexandra Eames | Glock 26 | . |
| Peter Scanavino | Johnny Feist | Heckler & Koch Mark 23 | "Diamond Dogs" (S5E02) |
| Saffron Burrows | Det. Serena Stevens | Glock 26 | - |
| Vincent D'Onofrio | Detective Robert Goren | Glock 19 | . |
| Vincent D'Onofrio | Detective Robert Goren | Remington 870 | . |