| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Charlize Theron | Anna Barnes-Leatherwood | Single Action Army | - |
| Charlize Theron | Anna Barnes-Leatherwood | Webley .455 Mk VI | dual-wielded |
| Liam Neeson | Clinch Leatherwood | Single Action Army | "Cavalry", "Artillery", and "Quick-Draw" models |
| Brett Rickaby | Charlie Blanche | Single Action Army | - |
| Evan Jones | Lewis | Single Action Army | "Cavalry" model |
| Jamie Foxx | Django Freeman | Single Action Army | - |
| Matt Clark | Old Prospector | Single Action Army | - |
| Neil Patrick Harris | Foy | Single Action Army | - |
| Neil Patrick Harris | Foy | Webley .455 Mk VI | - |
| Rex Linn | The Sheriff | 12 Gauge Double Barreled Shotgun | - |
| Rex Linn | The Sheriff | Richards Cartridge Conversion | - |
| Seth MacFarlane | Albert Stark | Single Action Army | - |
| Seth MacFarlane | Albert Stark | Webley .455 Mk VI | - |