| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Anne Hathaway | Agent 99 | SIG-Sauer P232 | - |
| Anne Hathaway | Agent 99 | SIG-Sauer P226 | - |
| Anne Hathaway | Agent 99 | SIG-Sauer P228 | Continuity error |
| David S. Lee | Ladislas Krstic | AKS-74U | - |
| Dwayne Johnson | Agent 23 | Desert Eagle | - |
| Ken Davitian | Shtarker | Walther P38 | - |
| Masi Oka | Bruce | Beretta 92FS | - |
| Steve Carell | Maxwell Smart/Agent 86 | SIG Sauer P226 | Standard model |
| Steve Carell | Maxwell Smart/Agent 86 | Sa vz. 61 Skorpion | - |
| Steve Carell | Maxwell Smart/Agent 86 | Beretta 92FS | - |
| Steve Carell | Maxwell Smart/Agent 86 | Colt Detective Special | 1st Generation model |
| Terry Crews | Agent 91 | Glock 17 | - |