| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Anthony Wong Chau-Sang | General Yang | Norinco Type 54 | - |
| Brendan Fraser | Rick O'Connell | M1928 Thompson | drum and stick magazines |
| Brendan Fraser | Rick O'Connell | PPSh-41 | - |
| Brendan Fraser | Rick O'Connell | Sten Mk II | - |
| Brendan Fraser | Rick O'Connell | Winchester Model 1912 | sawed off stock and barrel |
| Brendan Fraser | Rick O'Connell | M1911 | - |
| Brendan Fraser | Rick O'Connell | Smith & Wesson Model 10 | dual-wielded |
| Brendan Fraser | Rick O'Connell | Single Action Army | Cavalry Model |
| David Calder | Roger Wilson | Smith & Wesson Military & Police | - |
| David Calder | Roger Wilson | Browning Hi-Power | - |
| Jessey Meng | Choi | Browning M1919 | - |
| John Hannah | Jonathan Carnahan | Webley Mk VI | - |
| John Hannah | Jonathan Carnahan | Bren | - |
| Luke Ford | Alex O'Connell | PPS-43 | - |
| Luke Ford | Alex O'Connell | PPSh-41 | - |
| Maria Bello | Evelyn O' Connell | Browning Hi-Power | - |
| Maria Bello | Evelyn O' Connell | Colt Detective Special | - |
| Maria Bello | Evelyn O' Connell | Winchester Model 1894 | - |