| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Antonio Banderas | Agent Jeremiah Ecks | SIG-Sauer P226 | - |
| Antonio Banderas | Agent Jeremiah Ecks | Heckler & Koch MP5A2 | - |
| Antonio Banderas | Agent Jeremiah Ecks | Heckler & Koch FABARM FP6 | - |
| Antonio Banderas | Agent Jeremiah Ecks | Armsel Striker | - |
| Antonio Banderas | Agent Jeremiah Ecks | Heckler & Koch G36K | - |
| Antonio Banderas | Agent Jeremiah Ecks | M4A1 | - |
| Gregg Henry | Gant | M4A1 Carbine | - |
| Lucy Liu | Agent Sever | Heckler & Koch MP5A2 | - |
| Lucy Liu | Agent Sever | Beretta 92FS | - |
| Lucy Liu | Agent Sever | M4A1 Carbine | - |
| Lucy Liu | Agent Sever | FN P90 | - |
| Lucy Liu | Agent Sever | M60 | - |
| Lucy Liu | Agent Sever | AKS-74U | - |
| Lucy Liu | Agent Sever | Heckler & Koch USP | - |
| Ray Park | A.J. Ross | Beretta 92FS | - |
| Ray Park | A.J. Ross | Heckler & Koch MP5 | - |
| Roger R. Cross | Zane | Beretta 92FS | - |
| Roger R. Cross | Zane | DefTech 37mm launcher | - |
| Terry Chen | Harry | SIG-Sauer P228 | - |