| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Denzel Washington | Frank Lucas | Fegvergyar PJK-9HP | stainless steel finish, standing in for Browning Hi-Power |
| Denzel Washington | Frank Lucas | Colt Python | - |
| Denzel Washington | Frank Lucas | 12 Gauge Double Barreled Shotgun | - |
| Denzel Washington | Frank Lucas | CAR-15 | - |
| Armand Assante | Dominic Cattano | CZ Redhead O/U shotguns | - |
| Chiwetel Ejiofor | Huey Lucas | Smith & Wesson Model 629 | - |
| John Hawkes | Freddie Spearman | Colt Official Police | - |
| John Hawkes | Freddie Spearman | Ithaca 37 | - |
| Josh Brolin | NYPD Detective Trupo | Smith & Wesson Model 19 | snubnose |
| Ruben Santiago-Hudson | Doc | M1911A1 | - |
| Russell Crowe | Det. Richie Roberts | Smith & Wesson Model 64 | 3" heavy barrel |
| Russell Crowe | Det. Richie Roberts | Ithaca 37 | - |
| Yul Vazquez | Alfonse Abruzzo | Colt Official Police | - |
| Yul Vazquez | Alfonse Abruzzo | High Standard FLITE KING K-1200 Riot '''Standard''' Model | - |