| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Arthur Margetson | Dr. Sexton | Colt Detective Special | - |
| Basil Rathbone | Sherlock Holmes | Colt Detective Special | - |
| Basil Rathbone | Sherlock Holmes | Colt Police Positive | Only on a promotional image |
| Dennis Hoey | Inspector Lestrade | Colt Police Positive | - |
| Nigel Bruce | Dr. Watson | Colt 1877 Thunderer Shopkeeper Model | - |
| Nigel Bruce | Dr. Watson | Colt Police Positive | Only on a promotional image |