| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Audrey Tautou | Agent Sophie Neveu | Smith & Wesson Model 60 | - |
| Ian McKellen | Professor Teabing | Smith & Wesson Model 60 | - |
| Jürgen Prochnow | Andre Vernet | Glock 17 | - |
| Paul Bettany | Silas | Heckler & Koch USP | - |
| Étienne Chicot | Lieutenant Collet | SIG Pro SP2022 | - |