| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Basil Rathbone | Sherlock Holmes | Iver Johnson Bulldog | - |
| Basil Rathbone | Sherlock Holmes | Unidentified revolver | May beColt Lightning; Only on a promotional image |
| Dennis Hoey | Inspector Lestrade | Colt Commando | - |
| Lionel Atwill | Professor Moriarty | Webley Bulldog | - |
| Lionel Atwill | Professor Moriarty | Iver Johnson Bulldog | - |
| Lionel Atwill | Professor Moriarty | Compact top-break revolver | Only on a promotional still |
| Nigel Bruce | Dr. Watson | Webley Bulldog | - |
| Nigel Bruce | Dr. Watson | Iver Johnson Bulldog | - |
| Nigel Bruce | Dr. Watson | Colt Police Positive | Only on a promotional image |