| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Basil Rathbone | Sherlock Holmes | Webley Bulldog | - |
| Basil Rathbone | Sherlock Holmes | Colt Detective Special | - |
| Basil Rathbone | Sherlock Holmes | Iver Johnson Revolver | - |
| Dennis Hoey | Inspector Lestrade | Webley Bulldog | - |
| Dennis Hoey | Inspector Lestrade | Colt Detective Special | - |
| Dennis Hoey | Inspector Lestrade | Iver Johnson Revolver | - |
| Harry Cording | Captain John Simpson | Colt Detective Special | - |
| Nigel Bruce | Dr. Watson | Webley Bulldog | - |
| Nigel Bruce | Dr. Watson | Colt Detective Special | - |
| Nigel Bruce | Dr. Watson | Iver Johnson Revolver | - |