| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Ben Alexander | Officer Frank Smith | Smith & Wesson Model 10 | custom grips |
| Ben Alexander | Officer Frank Smith | Winchester Model 1912 | - |
| Harry Morgan | Det. Bill Gannon | Smith & Wesson Model 15 | - |
| Jack Webb | Det. Sgt. Joe Friday | Colt Detective Special | - |
| Jack Webb | Det. Sgt. Joe Friday | Smith & Wesson Model 10 | snub |
| Jack Webb | Det. Sgt. Joe Friday | Ithaca 37 | . |
| Roselyn Sanchez | Det. Elana Macias | Glock 26 | Two-Tone |