| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Benicio del Toro | Javier Rodriguez | Colt MK IV Series 70 | - |
| Clifton Collins Jr. | Francisco Flores | Heckler & Koch USP Compact | - |
| Don Cheadle | DEA Agent Montel Gordon | SIG-Sauer P228 | - |
| Jacob Vargas | Manolo Sanchez | Colt Mk IV Series 70 | - |
| Luis Guzmán | DEA Agent Ray Castro | Glock 17 | - |
| Yul Vazquez | Tigrillo | Remington 700 | Suppressed |