| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Benicio del Toro | Alejandro Gillick | Glock 17 | Gen 4 |
| Benicio del Toro | Alejandro Gillick | Heckler & Koch Mark 23 | Suppressed |
| Benicio del Toro | Alejandro Gillick | Heckler & Koch MP5A3 | Aimpoint sight, suppressor |
| Benicio del Toro | Alejandro Gillick | Glock 19 | Gen 3 |
| Benicio del Toro | Alejandro Gillick | Heckler & Koch MP5SD3 | - |
| Benicio del Toro | Alejandro Gillick | Beretta 92FS | - |
| Daniel Kaluuya | Reggie Wayne | Glock 17 | - |
| Daniel Kaluuya | Reggie Wayne | M4A1 Carbine | with EOTech sight |
| Emily Blunt | Kate Macer | Glock 19 | - |
| Emily Blunt | Kate Macer | M4A1 | - |
| Jeffrey Donovan | Steve Forsing | M4A1 | - |
| Josh Brolin | Matt Graver | Daniel Defense M4A1 | EOTech 553, Surefire M720V RAID light, and vertical grip |
| Maximiliano Hernández | Silvio | Beretta 92FS | Holstered |