| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Harrison Ford | Indiana Jones | Walther PPK | - |
| Harrison Ford | Indiana Jones | Walther P38 | - |
| Aïssam Bouali | Tangier mob henchman | Remington Model 870 Police Magnum | Sawed-off |
| Boyd Holbrook | Klaber | Walther P38 | - |
| Boyd Holbrook | Klaber | M1911 | - |
| Boyd Holbrook | Klaber | Walther PPK | - |
| Boyd Holbrook | Klaber | MG34 | - |
| Mads Mikkelsen | Dr. Jürgen Voller | Luger P 08 | - |
| Mads Mikkelsen | Dr. Jürgen Voller | Walther PPK | - |
| Mads Mikkelsen | Dr. Jürgen Voller | M1911 | - |
| Olivier Richters | Hauke | MAC-11 | suppressor |
| Thomas Kretschmann | Col. Weber | Luger P08 | - |
| Toby Jones | Dr. Basil Shaw | Luger P08 | - |