| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Carrie-Anne Moss | Trinity | Beretta Cheetah | - |
| Carrie-Anne Moss | Trinity | Micro Uzi | - |
| Carrie-Anne Moss | Trinity | Franchi SPAS-12 | - |
| Keanu Reeves | Thomas Anderson/Neo | GE M134 Minigun | Mounted on Bell 212 helicopter |
| Keanu Reeves | Thomas Anderson/Neo | Beretta 84FS Cheetah | - |
| Keanu Reeves | Thomas Anderson/Neo | Zastava CZ99 | - |
| Keanu Reeves | Thomas Anderson/Neo | Beretta 92FS | Dual-wielded |
| Keanu Reeves | Thomas Anderson/Neo | M16 (SP1) | - |
| Keanu Reeves | Thomas Anderson/Neo | Micro Uzi | Dual-wielded |
| Keanu Reeves | Thomas Anderson/Neo | Heckler & Koch SP89 | modified to resemble the MP5K; converted to full-auto, SEF Trigger Pack, Paddle Mag Release Lever, & MP5K Vertical Foregrip; Dual-wielded |
| Keanu Reeves | Thomas Anderson/Neo | Sa vz. 61 Skorpion | Muzzle shrouds; dual-wielded |
| Belinda McClory | Switch | Browning Hi-Power | With stainless steel finish and adjustable sights |
| Hugo Weaving | Agent Smith | Desert Eagle Mark XIX | - |
| Joe Pantoliano | Cypher | Heckler & Koch MP5K | Promotional material only |
| Julian Arahanga | Apoc | SWD M11/9 SMG | With barrel shroud |
| Julian Arahanga | Apoc | Zastava CZ99 | - |
| Matt Doran | Mouse | Custom Rotary Shotguns | designed by John Bowring |
| Robert Taylor (II) | Agent Jones | IMI Desert Eagle Mark XIX | - |