| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Boyd Kestner | Special Agent Burke | SIG-Sauer P226 | - |
| Giancarlo Giannini | Inspector Renaldo Pazzi | Beretta M1934 | - |
| Julianne Moore | FBI Special Agent Clarice Starling | SIG-Sauer P226 | - |
| Julianne Moore | FBI Special Agent Clarice Starling | Glock 17 | - |
| Julianne Moore | FBI Special Agent Clarice Starling | Smith & Wesson Model 65 | 3" Barrel, used in alternate ending |
| Terry Serpico | Detective Bolton | SIG-Sauer P226 | - |