| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Brian Geraghty | Fergus O'Donnell | M16A2 rifle | - |
| Brian Geraghty | Fergus O'Donnell | M203 grenade launcher | mounted on M16A2 rifle |
| Brian Geraghty | Fergus O'Donnell | Cobray 37mm Launcher | mounted on M16A2 rifle, switched with M203 in various shots |
| Brian Geraghty | Fergus O'Donnell | M18A1 Claymore | - |
| Brian Geraghty | Fergus O'Donnell | Beretta 92FS | - |
| Brian Geraghty | Fergus O'Donnell | L10A1SAW | - |
| Chris Cooper | Lt. Col. Kazinski | Beretta 92FS | holstered |
| Dennis Haysbert | Major Lincoln | Beretta 92FS | holstered |
| Evan Jones | Fowler | M16A2 | - |
| Iván Fenyö | Pinko | M16A2 | - |
| Jacob Vargas | Juan Cortez | M16A2 | - |
| Jake Gyllenhaal | Anthony "Swoff" Swofford | M16A2 | - |
| Jake Gyllenhaal | Anthony "Swoff" Swofford | M40A1 sniper rifle | - |
| Jake Gyllenhaal | Anthony "Swoff" Swofford | M67 hand grenade | - |
| Jamie Foxx | Staff Sgt. Sykes | M16A2 | fires paintballs |
| Jamie Foxx | Staff Sgt. Sykes | M60E3 | - |
| Jamie Foxx | Staff Sgt. Sykes | Beretta 92FS | - |
| Jamie Foxx | Staff Sgt. Sykes | M4A1 | RIS foregrip |
| Laz Alonso | LCpl Ramon Escobar | M40A1 | - |
| Laz Alonso | LCpl Ramon Escobar | M16A2 | - |
| Laz Alonso | LCpl Ramon Escobar | Cobray 37mm Launcher | mounted on M16A2 |
| Laz Alonso | LCpl Ramon Escobar | M67 hand grenade | - |
| Lucas Black | LCpl Chris Kruger | M40A1 | - |
| Lucas Black | LCpl Chris Kruger | M16A2 | - |
| Lucas Black | LCpl Chris Kruger | Beretta 92FS | - |
| Lucas Black | LCpl Chris Kruger | M67 hand grenade | - |
| Lucas Black | LCpl Chris Kruger | M60E3 | - |
| Peter Sarsgaard | Cpl. Alan Troy | M16A2 | Fitted with M203 Grenade Launcher |