| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Briana Venskus | Agent Piper | Smith & Wesson M&P | "Fear and Loathing on the Planet of Kitson" (S6E03) |
| Chloe Bennet | Daisy Johnson/Quake | Smith & Wesson M&P | "The Sign" (S06E12) |
| Christopher James Baker | Malachi | KRISS Vector | "New Life" (S6E13) |
| Clark Gregg | Sarge | Winchester Model 1897 Riot Gun | pistol grip, "Window of Opportunity" (S6E02) |
| Winston James Francis | Jaco | IWI Tavor TAR-21 | "Missing Pieces" (S6E01) |