| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Camille Mitchell | Nancy Adams | Beretta 92FS | - |
| Cassidy Freeman | Tess Mercer | Taurus PT92 | - |
| Emmanuelle Vaugier | Helen | Beretta 92FS Inox | "Phoenix" (S3E02) |
| Erica Durance | Lois Lane | Beretta 92FS | "Odyssey" (S8E01) |
| Jesse Metcalfe | Van McNulty | Heckler & Koch G36C | "Extinction" (S3E03) |
| Jill Teed | Agent Maggie Sawyer | Beretta 92FS | - |
| Kristin Kreuk | Lana Lang | Taurus PT92 | - |
| Kristin Kreuk | Lana Lang | SIG-Sauer P226 | "Phoenix" (S3E02) |
| Kyle Schmid | Sebastian Kane | Beretta 92FS | "Identity" (S8E07) |
| Michael Rosenbaum | Lex Luthor | Beretta 92FS Inox | - |
| Michael Rosenbaum | Lex Luthor | Mini-Uzi | "Hug" (S1E11) |
| Michael Rosenbaum | Lex Luthor | Desert Eagle Mark I | "Precipice" (S2E19) |
| Michael Rosenbaum | Lex Luthor | Jericho 941 | "Shattered" (S3E08) |
| Michael Rosenbaum | Lex Luthor | COP 357 Derringer | "Transference" (S4E06) |
| Michael Rosenbaum | Evil Lex | Bernardelli P-018 Compact | "Onyx" (S4E17)/stainless |
| Michael Rosenbaum | Lex Luthor | Glock 17 | "Lucy" (S4E16) |
| Michael Rosenbaum | Lex Luthor | Colt M1911A1 | "Mercy" (S5E19) |
| Michael Rosenbaum | Lex Luthor | Heckler & Koch USP | "Prototype" (S6E21) |
| Michael Rosenbaum | Lex Luthor | Taurus PT92AFS | Pearl grips |
| Steph Song | Victoria Sinclair/Roulette | Colt Mustang Plus II | Season 9, Episode 5 |
| William B. Davis | William Tate | Smith & Wesson Model 686 | "Relic" (S3E06) |