| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Charlton Heston | Col. Robert Neville | Browning Automatic Rifle | - |
| Charlton Heston | Col. Robert Neville | Smith & Wesson M76 | - |
| Charlton Heston | Col. Robert Neville | MP40 | - |
| Charlton Heston | Col. Robeert Neville | M1911A1 | - |
| Lincoln Kilpatrick | Brother Zachary | Star Model B | . |
| Paul Koslo | Dutch | M1A1 Thompson | - |
| Paul Koslo | Dutch | Single Action Army | - |
| Rosalind Cash | Lisa | Colt Model 1903/1908 | nickel plated with ivory grips |
| Rosalind Cash | Lisa | Smith & Wesson M76 | - |