| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Chloe Bennet | Daisy Johnson/Skye | Ruger P-series pistol | "Deal with our Devils" (S04E07) |
| Chloe Bennet | Daisy Johnson/Skye | Mossberg 500A Field Gun | Customized / "Self Control" (S04E15) |
| Chloe Bennet | Daisy Johnson/Skye | FN P90 | "Identify and Change" (S04E17) |
| Manish Dayal | Vijay Nadeer | SIG-Sauer P229R | "Borken Promises" (S4E09) |
| Troy Caylak | Yuri Zaikin | Fostech Origin-12 | "The Patriot" (S4E10) |
| Zach McGowan | Anton Ivanov | Makarov PM | Stainless; "All the Madame's Men" (S4E19) |