| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Chris Ashworth | Sergei Malatov | MAC-10 | "All Prologue" (S2E06) |
| Clarke Peters | Detective Lester Freamon | Makarov PM | "One Arrest" (S1E07) |
| Corey Parker Robinson | Detective Leander Sydnor | Glock | . |
| Domenick Lombardozzi | Det. Thomas "Herc" Haulk | Mossberg 500 Cruiser | pilot |
| Domenick Lombardozzi | Det. Thomas "Herc" Haulk | Glock 22 | - |
| Dominic West | Det. Jimmy McNulty | Glock 17 | - |
| Fredro Starr | Marquis "Bird" Hilton | Makarov PM | stainless steel finish |
| Gbenga Akinnagbe | Chris Partlow | Heckler & Koch USP | - |
| Gbenga Akinnagbe | Chris Partlow | Walther P99 | Silver Slide |
| J.D. Williams | Preston 'Bodie' Broadus | Glock 17 | - |
| J.D. Williams | Preston 'Bodie' Broadus | Beretta 92SB | Nickel plated |
| James Ransone | - | Glock 17 | - |
| Jamie Hector | Marlo Stanfield | Smith & Wesson 4506 | "Soft Eyes" (S04E02) |
| Lance Reddick | Lt Cedric Daniels | Glock 17 | - |
| Michael K. Williams | Omar Little | Double Barreled Shotgun | pistol gripped |
| Michael K. Williams | Omar Little | Mossberg 500 Cruiser | pistol gripped |
| Michael K. Williams | Omar Little | SIG-Sauer P226 | - |
| Michael K. Williams | Omar Little | Umarex GPDA | nickel plated |
| Michael K. Williams | Omar Little | Gold Cup National Match M1911A1 | stainless finish |
| Michael K. Williams | Omar Little | Desert Eagle | - |
| Michael K. Williams | Omar Little | Ruger P90 | dual-wielded |
| Michael K. Williams | Omar Little | Colt Anaconda | - |
| Michael K. Williams | Omar Little | Taurus PT92 | - |
| Wendell Pierce | Detective 'Bunk' Moreland | Glock | "Old Cases" |