| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Matt Damon | Collin Sullivan | SIG-Sauer P226 | - |
| Matt Damon | Collin Sullivan | Astra A-100 | - |
| Matt Damon | Collin Sullivan | Walther PPK | flat-nickel plated |
| Anthony Anderson | Det. Brown | SIG-Sauer P226 | - |
| David O'Hara | "Fitzy" Fitzgibbons | Smith & Wesson Model 36 | - |
| Jack Nicholson | Frank Costello | Beretta Cheetah | - |
| Jack Nicholson | Frank Costello | Smith & Wesson Model 19 Snub Nose | - |
| James Badge Dale | Trooper Barrigan | Walther PPK | - |
| James Badge Dale | Trooper Barrigan | SIG-Sauer P226 | - |
| Leonardo DiCaprio | Billy Costigan | Astra A-100 | substitute forSIG-Sauer P226 |
| Leonardo DiCaprio | Billy Costigan | Walther PPK/S | - |
| Leonardo DiCaprio | Billy Costigan | SIG-Sauer P226 | - |
| Mark Rolston | Timothy Delahunt | Mossberg 500 Cruiser | - |
| Mark Wahlberg | Staff Sergeant Sean Dignam | SIG-Sauer P226 | - |
| Mark Wahlberg | Staff Sergeant Sean Dignam | Beretta 92FS | suppressed |
| Martin Sheen | Capt. Oliver Queenan | SIG-Sauer P226 | - |
| Ray Winstone | Mr. Arnold French | Colt Python | snubnose |
| Leonardo DiCaprio | Billy Costigan | SIG-Sauer P226 MK25 | - |