| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Matt Damon | Jason Bourne | SIG Pro SP2022 | - |
| Matt Damon | Jason Bourne | Beretta 92FS | - |
| Matt Damon | Jason Bourne | Glock 17 | - |
| David Strathairn | Noah Vosen | Glock 17 | - |
| Edgar Ramirez | Paz | SIG SG 552 | scoped and suppressed |
| Edgar Ramirez | Paz | SIG-Sauer P229 | suppressed |
| Edgar Ramirez | Paz | Beretta 92SB | - |
| Joan Allen | Pamela Landy | Glock 17 | - |
| Joey Ansah | Desh | Heckler & Koch USP Compact Tactical | With & without suppressor |
| Scott Adkins | Agent Kiley | SIG Pro SP2022 | - |