| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Will Smith | Capt. James "Jim" West | Colt 1861 Navy | - |
| Will Smith | Capt. James "Jim" West | Colt 1862 Police | Nickel Plated |
| Will Smith | Capt. James "Jim" West | Winchester Model 1873 | Cut-down to resemble "Mare's Leg" |
| Frederique Van Der Wal | Amazonia | Gatling Gun | - |
| Frederique Van Der Wal | Amazonia | Remington 1858 New Army | - |
| Kenneth Branagh | Dr. Arliss Loveless | Wheelchair-mounted Shotguns | - |
| Kevin Kline | Artemus Gordon | Colt Theur Derringer | - |
| Musetta Vander | Munitia | Smith & Wesson Schofield Model 3 | - |
| Musetta Vander | Munitia | Henry 1860 | - |
| Ted Levine | General McGrath | Single Action Army | Uberti replica, "Cavalry" model with brass grip frames and wooden grips |