| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Will Smith | Robert Neville | Colt Law Enforcement Model 6920 Carbine | PentagonLight MD3R, Trijicon ACOG, Knights Armament RAS, ERGO Rail Covers |
| Will Smith | Robert Neville | Heckler & Koch Mark 23 | - |
| Will Smith | Robert Neville | Beretta 92FS | - |
| Will Smith | Robert Neville | M67 hand grenade | - |
| Will Smith | Robert Neville | Smith & Wesson 5946 | - |
| Alice Braga | Anna | Glock 19 | . |
| Alice Braga | Anna | Beretta 92FS | alternate ending |
| Darrell Foster | U.S. Army Ranger | Special Weapons SP-10 | - |