| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Milla Jovovich | Alice | Beretta 92FS Inox | - |
| Milla Jovovich | Alice | Springfield Armory Mil-Spec M1911A1 | stainless steel |
| Milla Jovovich | Alice | High Standard K-1200 Riot Deluxe Shotgun | - |
| Colin Salmon | One | Heckler & Koch G36K | - |
| Colin Salmon | One | AG36 grenade launcher | mounted on H&K G36K |
| Colin Salmon | One | M1911A1 | with stainless steel finish |
| James Purefoy | Spencer | M1911A1 | - |
| Liz May Brice | female medic | Walther P99 | - |
| Martin Crewes | Chad Kaplan | Taurus Model 431 | - |
| Martin Crewes | Chad Kaplan | Heckler & Koch MP5KA4 | - |
| Michelle Rodriguez | Rain Ocampo | Springfield Armory Mil-Spec M1911A1 | Pachmayer grips |
| Michelle Rodriguez | Rain Ocampo | Heckler & Koch MP5K | Walther scope and magazines clamped together |
| Pasquale Aleardi | J.D. Salinas | Smith & Wesson 5906 | - |
| Pasquale Aleardi | J.D. Salinas | Heckler & Koch G36K | - |