| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Cobie Smulders | Shannon Bell | Bernardelli P-018 Compact | Stainless; "Bound" (S4E02) |
| Erica Durance | Lois Lane | "M1-L1 Triple-Pulse Rifle" | Calico M955Aoriginally modified forDeep Rising; "Gone" (S4E02) |
| Jane Seymour | Genevieve Teague | SIG-Sauer P230 | "Commencement" (S4E22) |
| Jensen Ackles | Jason Teague | Bernardelli P-018 Compact | Stainless; "Forever" (S4E21) |
| Jensen Ackles | Jason Teague | Winchester Model 1912 Riot Gun | "Commencement" (S4E22) |