| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Milla Jovovich | Alice | Para-Ordnance Nite-Tac | (dual wielded) |
| Milla Jovovich | Alice | Mossberg 590 Compact Cruiser | - |
| Ali Larter | Claire Redfield | Glock 17 | - |
| Ali Larter | Claire Redfield | Winchester Model 1894 | with crossbolt safety |
| Ashanti Douglas | Nurse Betty | Smith & Wesson 5946 | - |
| Christopher Egan | Mikey | Taurus PT92 | - |
| Linden Ashby | Chase | L85A1 | M68 Aimpoint Scope |
| Linden Ashby | Chase | Smith & Wesson Model 29 | - |
| Matthew Marsden | Slater | Beretta 92FS | - |
| Mike Epps | L.J. | Desert Eagle | Gold-plated |
| Oded Fehr | Carlos Olivera | BRS-99 | - |
| Oded Fehr | Carlos Olivera | Taurus PT92 | - |
| Oded Fehr | Carlos Olivera | Heckler & Koch USP | - |
| Spencer Locke | K-Mart | Winchester 1300 | - |