| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Milla Jovovich | Alice | Heckler & Koch MP5K | - |
| Milla Jovovich | Alice | 12 Gauge Double Barreled Shotgun | (dual wielded) |
| Milla Jovovich | Alice | Smith & Wesson Model 460V | (dual-wielded) |
| Ali Larter | Claire Redfield | Beretta 90Two | - |
| Boris Kodjoe | Luther West | Taurus PT92 | - |
| Kacey Barnfield | Crystal | Smith & Wesson Model 460V | - |
| Kim Coates | Bennett Sinclair | SIG-Sauer P230 | ivory grips |
| Norman Yeung | Kim Yong | Heckler & Koch HK91 | - |
| Sergio Peris-Mencheta | Angel Ortiz | Heckler & Koch HK91 | - |
| Sergio Peris-Mencheta | Angel Ortiz | Heckler & Koch P2A1 | - |
| Shawn Roberts | Albert Wesker | Desert Eagle | dual-wielded |
| Sienna Guillory | Jill Valentine | Brügger & Thomet MP-9 | holstered on dual thigh holsters |
| Wentworth Miller | Chris Redfield | Beretta 93R | - |
| Wentworth Miller | Chris Redfield | Smith & Wesson Model 460V | - |