| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Sigourney Weaver | The "Big Guy" | Colt Python | Stainless, 6 inch barrel, pearl grips |
| Bill Hader | Agent Haggard | Glock 19 | - |
| Bill Hader | Agent Haggard | Standalone M203 Grenade Launcher | - |
| Jason Bateman | Special Agent Lorenzo Zoil | SIG Pro SP 2009 | - |
| Jason Bateman | Special Agent Lorenzo Zoil | M4A1 Carbine | M68 Aimpoint Scope, Surefire M900 weapon forelight |
| Joe Lo Truglio | Agent O'Reilly | Glock 19 | - |
| John Carroll Lynch | Mose Buggs | 12 Gauge Double Barreled Shotgun | - |