| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Daniel Henney | David North/Agent Zero | Taurus PT92 | dual-wielded |
| Daniel Henney | David North/Agent Zero | Beretta 92 FS | suppressor |
| Daniel Henney | David North/Agent Zero | SVD Dragunov | - |
| Daniel Henney | David North/Agent Zero | AK-47 | slung over back |
| Danny Huston | Col. William Stryker | M1911A1 | holstered |
| Danny Huston | Col. William Stryker | Ruger Redhawk | stainless model loaded with adamantium bullets |
| Dominic Monaghan | Chris Bradley/Bolt | Zastava M70B2 | foldable stock |
| Hugh Jackman | James Howlett | Enfield Pattern 1853 | - |
| Hugh Jackman | James Howlett | M1903 Springfield | - |
| Hugh Jackman | James Howlett | Mauser Gewehr 1898 | - |
| Hugh Jackman | James Howlett | M1A1 Thompson | - |
| Hugh Jackman | James Howlett | Colt Model 733 | - |
| Hugh Jackman | James Howlett | Browning M2HB | - |
| Hugh Jackman | James Howlett | Zastava M70B2 | - |
| Kevin Durand | Fred J. Dukes/The Blob | M60 | - |
| Liev Schreiber | Victor Creed/Sabretooth | M60 machine gun | - |
| Liev Schreiber | Victor Creed/Sabretooth | Mauser Gewehr 1898 | - |
| Liev Schreiber | Victor Creed/Sabretooth | MG34 | - |
| Liev Schreiber | Victor Creed/Sabretooth | M1903 Springfield | - |
| Liev Schreiber | Victor Creed/Sabretooth | British 1853 Enfield | - |
| Liev Schreiber | Victor Creed/Sabretooth | M1911A1 | - |
| Liev Schreiber | Victor Creed/Sabretooth | Browning Automatic Rifle | - |
| Will I Am | John Wraith | Heckler & Koch G36K | fitted with AG36 grenade launcher; anachronistic |
| Will I Am | John Wraith | Zastava M70B2 | foldable stock |