| Actor | Character | Firearm | Notes |
|---|---|---|---|
| David Hyde Pierce | Niles Crane | Starter's Pistol | "She's The Boss" (S03E01) |
| David Hyde Pierce | Niles Crane | Glock 19 | "Analyzed Kiss" (S10E23) |
| Dennis Cockrum | Red | Heckler & Koch USP | Two-tone "Analyzed Kiss" (S10E23) |
| John Kapelos | Police Officer | Beretta 92FS | "The Ann Who Came To Dinner" (S11E13) |
| John Mahoney | Martin Crane | Glock 19 | "Analyzed Kiss" (S10E23) |