| Actor | Character | Firearm | Notes |
|---|---|---|---|
| DeForest Kelley | Dr. Leonard McCoy | Smith & Wesson Model 10 | "Tomorrow is Yesterday" (S01E19) |
| DeForest Kelley | Dr. Leonard McCoy | Colt 1921AC Thompson | "A Piece of the Action" (S02E17) |
| DeForest Kelley | Dr. Leonard McCoy | Single Action Army | "Spectre of the Gun" (S03E06) |
| George Takei | Lt. Hikaru Sulu | Smith & Wesson Model 10 | (episode: "Shore Leave") |