| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Ed Asner | Klaus Braun | Luger P08 | "Yahrezit" (S05E22) |
| Emilio Rivera | Little Stevie | AKMSU | "Point of No Return" (S5E18) |
| Emmanuelle Vaugier | Det. Jessica Angell | Glock 17 | . |
| Gary Sinise | Det. Mac Taylor | Luger P08 | "Yahrezit" (S5E22) |
| Geoff Meed | Ronnie DeSoto | Taurus PT911 | "Greater Good" (S05E23) |
| Jonah Lotan | Dr. Marty Pino | Glock 17 | "Point of No Return" (S05E18) |
| Jonah Lotan | Dr. Marty Pino | Beretta 92SB | "Point of No Return" (S05E18) |
| Melina Kanakaredes | Det. Stella Bonasera | Remington 870 | "Enough" (S05E06) |