| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Eddie Murphy | Axel Foley | Browning Hi-Power | - |
| Eddie Murphy | Axel Foley | Ithaca 37 | pistol grip |
| Gilbert R. Hill | Inspector Douglas Todd | Colt MK IV Series 70 | - |
| John Ashton | Det. Sgt. John Taggart | Smith & Wesson Model 19 | - |
| John Ashton | Det. Sgt. John Taggart | Ithaca 37 | - |
| Jonathan Banks | Zack | Charter Arms Pink Lady | - |
| Jonathan Banks | Zack | Smith & Wesson 3000 Shotgun | Pistol grip with folding stock |
| Judge Reinhold | Det. William "Billy" Rosewood | Colt Detective Special | - |
| Michael Champion | Casey | Smith & Wesson 639 | - |
| Paul Drake | Strip club robber | Ithaca 37 | - |
| Paul Reiser | Det. Jeffrey Friedman | Smith & Wesson 639 | in waistband |
| Ronny Cox | Lt. Andrew Bogomil | Smith & Wesson 639 | - |
| Steven Berkoff | Victor Maitland | Smith & Wesson Model 629 | - |
| Tom Everett | Holdup Man #2 | 12 Gauge Double Barreled Shotgun | short barreled |