| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Gabrielle Anwar | Rebecca Doyle | Double ActionDerringer | Only on film poster |
| James D'Arcy | Sherlock Holmes | Lefaucheux Revolver | Nickel plated and blued |
| James D'Arcy | Sherlock Holmes | Gasser Montenegrin M1880 | - |
| James D'Arcy | Sherlock Holmes | Rast-Gasser M1898 | - |
| James D'Arcy | Sherlock Holmes | Taurus Model 65 | - |
| James D'Arcy | Sherlock Holmes | Cane gun | - |
| Nicholas Gecks | Inspector Lestrade | Lefaucheux Revolver | - |
| Nicholas Gecks | Inspector Lestrade | Gasser Montenegrin M1880 | - |
| Nicholas Gecks | Inspector Lestrade | Webley Bulldog | - |
| Vincent D'Onofrio | Moriarty | Rast-Gasser M1898 | - |
| Vincent D'Onofrio | Moriarty | Lefaucheux Revolver | - |