| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Adewale Akinnuoye-Agbaje | Lock-Nah | Lee-Enfield No.1 Mk.III* | - |
| Adewale Akinnuoye-Agbaje | Lock-Nah | Mauser C96 | akimbo |
| Brendan Fraser | Rick O'Connell | Winchester Model 1887 | - |
| Brendan Fraser | Rick O'Connell | M1911A1 | dual-wielded |
| Brendan Fraser | Rick O'Connell | Smith & Wesson "Triple Lock" | . |
| Brendan Fraser | Rick O'Connell | Double Barreled Shotgun | sawed-off |
| Bruce Byron | Red | Smith & Wesson Military & Police | - |
| Bruce Byron | Red | FN Hi-Power | - |
| John Hannah | Jonathan Carnahan | Lee-Enfield No III* Mark I SMLE | - |
| Oded Fehr | Ardeth Bay | Colt 1921A Thompson | - |
| Patricia Velasquez | Meela Nais | Steyr-Solothurn S1-100 | - |
| Quill Roberts | Shafek | Mauser C96 | - |
| Quill Roberts | Shafek | Luger P08 | - |
| Rachel Weisz | Evelyn Carnahan O'Connell | Lee-Speed Sporter | - |
| Rachel Weisz | Evelyn Carnahan O'Connell | M1911A1 | - |
| Rachel Weisz | Evelyn Carnahan O'Connell | Winchester Model 1887 | - |