| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Jake Gyllenhaal | John Morris | Colt 1851 Navy | - |
| Jake Gyllenhaal | John Morris | Sharps Carbine | M1859orM1863 |
| Joaquin Phoenix | Charlie Sisters | Colt 1851 Navy | - |
| Joaquin Phoenix | Charlie Sisters | Sharps 1874 | - |
| John C. Reilly | Eli Sisters | Colt 1851 Navy | - |
| Richard Brake | Rex | Colt 1851 Navy | - |
| Riz Ahmed | Hermann Kermit Warm | Colt 1849 Pocket | - |