| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Joe Piscopo | Danny Vermin | Colt New Service | With custom long barrel, as ".88 Magnum revolver" |
| Michael Keaton | Johnny Kelly/Johnny Dangerously | Smith & Wesson Model 36 | - |
| Michael Keaton | Johnny Kelly/Johnny Dangerously | Thompson M1928 | Replica |
| Peter Boyle | Jocko Dundee | Colt Detective Special | - |
| Richard Dimitri | Roman Troy Moronie | Colt Detective Special | - |
| Richard Dimitri | Roman Troy Moronie | Colt Model 1903 Pocket Hammerless | - |
| Richard Dimitri | Roman Troy Moronie | M1928A1 Thompson | - |