| Actor | Character | Firearm | Notes |
|---|---|---|---|
| John C. Reilly | Dr. Watson | Webley .455 Mk IV | or Mk V |
| John C. Reilly | Dr. Watson | Colt Official Police | - |
| Kelly Macdonald | Mrs. Martha Hudson | Webley .38 Mk IV | - |
| Lauren Lapkus | Millicent | Coach Gun | - |
| Rebecca Hall | Grace Hart | Single Action Army | - |
| Will Ferrell | Sherlock Holmes | Webley RIC No.1 New Model | - |
| Will Ferrell | Sherlock Holmes | Enfield Mk II | Promotional materials only |